Quote Originally Posted by OldRod_KS View Post
OK, I did that and now I can see in the other window, it switches target to the creature I'm fighting, but then I get a message "Target not enemy", so it's trying to cast, but it thinks it can't. Do I need a slight delay in there to make sure the target has switched before casting?

*edit* I clicked "Do not advance to the next step for at least 0.1 seconds" and that didn't help.

Just for fun, I tried rebinding that hotkey slot to "E" and changed my keymaps in ISBoxer to use E instead of Alt-1. Still no change.
Try setting your DPS Abilities in the First Step of your DPS Rotation key and the Assist Me key in a Second Step. It may be that you are calling the DPS Ability while the Slave is targeting your Lead to aquire his/her target.