For PvE I don't see any type of setup being a problem, but for PvP I would probably agree since you may have the need to instantly switch Lead if your Lead dies. Altough that should be possible to "fix" by simply using a similar system where you pre-define keys before a match begins. The potential problems that could still occur, off of the top of my head, would be if someone leaves the WarZone and someone else joins (assuming this is possible, I haven't done any PvP yet) and as a result shifts around the Party again that you are in with your characters. But other than that, and the hassle of cycling through keys before each match, it should work.
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