It's all about the macros and key bindings, imo. Once you know how to write efficient macros and have your bindings set for what works for you, then you can make just about any combo work as long as you like playing it. Personally, I don't like the positional requirements of melee classes when I multi-box, but someone else might really enjoy it. Try many variations and see if you like it. I have so many lowbie teams of various compositions that I really need to go back and clean up. Anyhow, good luck to you and have fun!