If something in the game world can be interacted with, yet you cannot target it, then the only way is to use your mouse, either by:
A) Right-clicking on the physical location in the game world
B) Hovering your mouse over the physical location in the game world, and using Interact with Mouseover
If you aren't willing to broadcast your mouse while multiboxing, then your only option is to switch windows and interact with the item/node in question.
Also, I made a mistake by moving this thread, and I'll move it back.
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