I'll just throw this out there, but if you're using DX12 while multiboxing you may be sabotaging yourself. Lax only recently implemented DX12 support into Inner Space, but when I tested it out I had horrid performance when DX11 was perfect, so I'd double-check your DirectX setting in the "Advanced" section of the game's settings.
Also, if you're using any form of anti-aliasing that's also going to crush a setup that is walking the fine line between good and bad performance. I know you said you're using the lowest setting on the slider, but moving the slider doesn't affect the AA setting.
EDIT: It would seem that you may not experience issues with DX12 as long as your driver is up to date. Upon re-visiting DX12 while multiboxing, performance is now very good.
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