For WoD I just have been sending the corresponding ingame keybind and stored my macros ingame per character as well. However since I have Beta access, I have completely reworked my setup in preparation and made separate ISBoxer macros for each and every spell on all of my classes and specs. So as soon as the expansion prepatch lands, I will be 100% in ISBoxer (apart from click healing, which I will just handle with Clique/Vuhdo and a repeater region)
The overhaul was made a lot easier by utilizing the dummy macro set Luxlunae provided in a somewhat recent blog post. Although some of the binds did interfere with my existing ones, but that was easy enough to fix.
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