I just started using the gnomesequencer addon myself.. im getting good results..BUT i combine it with isboxer and priority+steps to further optimize my DPS. my item lvl 626 Fury warrior was doing burst 21k dps in 5 mans yesterday with 15k sustained throughout the instance. And im new to the class.. so im sure i can up the dps with further refinements.
I have yet to using it on any other classes but based on what i have read, it seems to favor non casting classes..ie hunters..melee..tanks. I will be trying it out with all my toons and see if i can get better results than without it.
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