I personally go with Grid + Grid Custom Layouts + Clique.

Grid and Custom Layouts gets me the entire raid in a 5-row deep, 8-column wide grid.
My five toons are always in the left-most vertical column.
The rest of the raid is in columns two through eight.
It is an alphabetical sort, so its the same on every screen.
http://www.dual-boxing.com/threads/4...870#post347870

With Clique, I've set various clicks to be specific heals.
With my 5x Resto Druid team, I use:
- Left = Rejuvenation
- Right = Cleanse
- Ctrl Left = Lifebloom
- Ctrl Right = Regrowth
- Alt Left = Nourish
- Alt Right = Healing Touch
- Scroll Up = Swiftmend
- Scroll Down = Wild Growth

The logic is: Left/Right clicks are used frequently, the scroll wheel for AoE (as Swiftmend triggers Efflorescence), ctrl clicks for emergency (less efficient) heals, and alt clicks for efficient (but slower) heals.



On my Paladin / 4x DK team, I use:
- Left = Flash of Light
- Right = Divine Light
- Alt + Left = Holy Shock
- Alt + Right = Word of Glory
- Mouse Thumb = Cleanse




I place an IS Boxer Repeater Region over the entire grid.
And have it send the clicks (KVM Mode, to block local clicks) to the Healer or Healer Group.

That way, from any toon, I can mouse over the Grid and make a simple click.
It won't make my tank/dps toons change targets, but my healer then does the appropriate heal.