what is the best combo?

[Boylston]

We don't know the best combo. Currently it appears to be shaman based but this is just a guess. Different combos do better in different situations and the effectiveness can vary greatly to the point where instead of figuring out the best combo we just figure out what we want to do and then combine what would be effective in that area and what we enjoy. That or we just copy someone else.

Also with "balance" changes, the best combo could change at any time, so unless you like leveling, I'd suggest going with something that you'll enjoy even if it isn't the best.

This is a very accurate assessment of the current state of WoW multi-boxing. I think that even if there was some "best" out there, there's probably some amazing class combinations that are currently way under-represented because they haven't had good PR reps like the shammies have. For example, I think multi-hunters will show themselves to be very potent, in time.