Sure you could use your event multiplexer to click a region. I have a few regions on my main off near the minimap with a dummy "kgpanel" (like what decursive unit frames looks like), when i click that area hotkeynet clicks or right clicks the area on the slave(s). right above the player model.
I am sure isboxer does the same thing. Definately no need to use the slaves for handing in quests and taking portals, unless somehow they get in the wrong area (they go before the leader is what I try for)
If you get a water / heal stone trading addon you can do away with a lot of trade issues as well. I usually trade all the leather to one character and cloth to another and so forth. I dont recall the water macro, but it allows you to trade anything and use white lists. So if you open trade to the character it will toss all its cloth into a window essentially. Then you just need to macro that trades between the slaves. But that stuff is rare (well maybe as rare as portals).
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