Vuhdo can do this also. Create your click sequence macro and call it something that is not the same as a spell name.
Open the Vuhdo config and click on the spells tab. Tick the box which allows macro casting and type in the name of your macro next to the left click key.
I use a mouse with 6 buttons which allows me to call 6 different spells with my right hand, whilst I drive and dps with my left on the keyboard. I know some of the guys have a naga configured with click heals which lets you cast a lot more spells/macros from your mouse hand without key modifiers required.
The other thing I like about this setup is that for BGs it lets me be an effective raid healer whilst still watching and healing my team fine too.
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