As long as it's one action per keypress, it doesn't matter whether it correlates to a button press or mouse click. The only problem with mouse click stuff is when you do other things than simply position the mouse cursor and click. For example, positioning the mouse cursor on an alt's screen based on where a mob is located (i.e.: "bot" targeting similar to the UT2004 aimbots did). As long as you're just repeating the mouse click location from the main or having it perform a basic click somewhere, things should be fine.