I've never had interact with target (IWT) fail to work. I use the IWT as generated by the Quick Setup Wizard, and I use it manually as opposed to added onto my DPS keys.

With that said, to understand how your IWT might be failing to work I need to see your configuration. To share it, use "Copy ISBoxer Toolkit Profile to Clipboard" from the File menu in ISBoxer, then paste it on pastebin.com and share the link. The copy to clipboard option gives you privacy controls to hide your account names (hidden by default) and character names (not hidden by default) so please don't just open the XML file and copy it manually.