Depends on the magnitude of the gimmick. Obviously, the devs have stated the DK talent trees will be completely overhauled and tanking separated out to the blood tree. It's the hardest class to theorycraft at this point, in my opinion.
I will guess that the DK's nifty anti-heal ability will do a fairly large amount of "damage" if you consider the sum of real+anti-heal as "damage". If it did stack, one could imagine it being a very potent combo. In today's values, imagine if you could use an ability across multiple characters to negate 20-30,000 points of heals. Would that "gimmick" be significant reason to run an all DK comp.... Might be! (Probably would make Healer+4xDK pretty uber in arenas...)
Fundamentally, I agree with you.Any time there's new abilities or gameplay mechanics that go in, I think there's a chance that it turns our best comps list upside down.
No one ever thought melee boxing was possible, and 4-5xHunters was a pretty popular comp that myself, Ellay, Vyndreamy, and others explored at the end of BC...
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