Just sharing what may help some engineers,

I did many a search about this last year because of how F3 would open "Search Results" in windows. I was looking for ways to disable windows defaults like that too.
In the end, it turned out my keyclone was auto-adding windows and I just had to turn off "Auto-add", and then it wouldn't accidentally transmit F3 to outside of WoW.
But one thing I discovered was a lot of people trying to disable the windows key (Between CTRL and ALT). There was a whole thread about a $60 product you could buy that finally let you re-map windows defaults like F1 and F3 and the windows key (which is just a CTRL-ESC combo).
Then someone says "Get a screwdriver and some pliers. There, I just saved you 60 bucks"
I've never seen someone so grateful.