So, it looks like the best option is still to put all your money into 1 GFX card and split of multiple monitors from there. SLI/Crossfire may get you some help, but it doesn't look promising due to issues with SLI and Crossfire and a general lack of support from Blizz. I'm bummed cause I was hoping to set up 5-boxing with a 30" in the center and 2x 24" on either side (turned on thier side - aka portrait). But I'm not thinking even something like a 295 will push good FPS for a main on 2560x1600 and 4 slaves @ 1200x960. I'm not even sure how to hook up 3 monitors without getting into the problems off a single card. Maybe go SLI/Crossfire just for the extra physical hookups?

Does anyone know if there are any issues a 295 or 4870X2 (or any card that is essentially 2 GFX cards soldered together internally)?