AFAIK, there is no way to move the mouse with in-game macros, so the only method of getting the 30-yard out AE that you described without using software would be to keep the mouse pointer exactly where you want it and leave it there.

For point blank range though, there is another solution. You can save your own camera angle. What I do is a save a camera angle that is zoomed all the way in and pointing down at the ground. Therefore, the mouse pointer, wherever it may be, will result in the center of the AE spell being within a couple yards of the character. The hitch to this method is that for some stupid reason, even though you can save custom camera angles easily through normal in-game functions, it is apparantly impossible to save those custom camera angles across sessions. So as soon as you log out, you lose it. So I've resorted to quickly zooming in the camera on all my toons, saving the angle with a set keybinding, and then everything is peachy for that particular play session. It's kind of annoying, but only takes a few seconds every time I log in. The default camera angles don't seem to be zoomed in enough to safely use for point blank AE.

If anyone has found any way to save custom camera angles so they stay even when you log out, I'd love to hear it.