I recently switched to using ISBOXER macros and the pro system. I saw a 10-20% dps increase, overall. I also recently swapped to focus macros for targeted healing. The green click bar displays which character is currently being focused, the orange one shows which characters will cast interrupt and stun.
I've found you can ignore ticks after he tantrums so long as you have enough dps. You can keep your tank alive for probably 10-20 seconds before you get overwhelmed. I had plenty of time on this kill, I think I could do this on a +10 on a fortified week and the route is a little easier since you skip all the trash from the top to the first boss with Awakened.
The last boss is a supreme joke, but if you don't know what's going on it can be difficult.
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