You can probably use macro like this (I haven't tested it, but I assume it will work):
/use [@player] GrenadeName
For ranged it would be good if you could get round robin on the grenades so you can have another way to interrupt but not too convenient to use.
To reduce amount of keys you need to press you can try to see if you can get this to work to just have to just have to press hotkey and not mouse click, need to have cursor at right location though:
/use [@cursor] GrenadeName
I don't think the damage will be worth using grenades.
I think for pvp you want to use Goblin Sapper Charge.
You will have to spend a lot of gold to lvl engineering and to use the consumables. For pvp it can be worth it, for pve it is not worth it imo.
5 Goblin Sapper Charge = 10 Mageweave Cloth, 5 Mithril Bar, 40 Solid Stone. Quite a lot of gold to throw away with a press of a hotkey.
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