I actually remembered to record a run: Here's a +6 run of Waycrest Manor done last week (Fortified, Sanguine). I commentate throughout and try to explain what I'm doing and what I'm thinking about as I run through the dungeons.

Its not a perfect run, but it demonstrates some of the strategies. Its a shame, because I did a nearly flawless +5 run just before this that I didn't think to record. I'm beginning to grow wary of Raal; I still reckon Heartsbane is the harder boss but Raal is clearly also going to be a block on Tyrannical progress. I need a more robust strategy for him, as I discuss in the video.