First, if you have multiple sets of Key Maps like Combat and WoW-Combat, then you need to see which are attached to the Character Set you're trying to alter. However, if you're unsure why you've got multiple sets of Key Maps when your profile is only for one game (e.g. WoW), then you could just be adding unnecessary work and confusing yourself by having all of those extra Key Maps.
Second, if you're setting Hotkeys for Mapped Keys in ISBoxer which call the macros stored in the Game Helper section and they're not firing off in game, then that means:
A) The ISBoxer add-on is disabled
B) You've removed or altered key combinations to macros in the Game Helper section which are being used by these Mapped Keys
C) You've unassigned (or forgot to assign) macros to a Character or Character Set in the Game Helper section
D) You're playing on a private server where the ISBoxer add-on doesn't work
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