I've been using E-centric bindings for a few years now and I can't imagine ever going back to WASD. Personally, I use WER for strafing/movement with Follow typically bound to D (I don't backpedal). I use three banks of keys for binding:
1 2 3 4 5 6
Q A S F G T (and optionally Y)
Z X C V B N (all of these can be reached with your thumb)
The beauty of shifting the hand over to WER, I find, is that it allows me to hit CTRL with the part of my hand just below the pinky finger. This acts like a 6th finger and doesn't require me to move my other fingers out of position--effectively doubling the number of easy-to-reach keybinds. This trick is entirely awkward to use in a WASD-setup from my experience.
I think it took me several days to adjust when I originally made the switch. But now I spam the 1 key with my pinky as if it was the only way to do it. And think, you'll be a five-fingered gamer again, just like the gamer gods intended. No more four-finger handicap for you.
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