I would also recommend going with HotKeyNet over AutoHotkey. But after you've multiboxed for as long as some of us have, you'll probably realize you don't want to write so many boilerplate scripts for every team and every little change you make to them and just go with ISBoxerA lot of us multibox because we have less uninterrupted time to just sit down and play WoW, and ISBoxer actually lets me spend more time playing rather than fiddling and setting up stuff.
ISBoxer also has a number of features that are almost impossible, or impractical to do with HotKeyNet or any other sort of scripting program, for example mouse repeater regions for click healing and instant PiP swapping. The automatic FTL (focusless, targetless, leaderless) setup stops you from having to make billions of /assist focus macros for every single DPS spell. If you run multiple classes or specs, you'd find great use of Action Target Groups. There's also a few nifty things that are a nightmare to do otherwise, like sending the next click to all windows for targeted AoE spells.
I used to have problems all the time with "runners" (one or more characters with auto-run stuck on, uncontrollably running away into the distance), window switching delays, cameras spinning around wildly, hotkeys getting stuck, etc. when I was a AHK/HKN scripter but I don't have to deal with that anymore for ISBoxer. I recommend you at least try the free trial and see how you like it.
Edit: And you'll get tons of support. The creator of the program, Lax, posts here regularly and other posters like Ualaa have been very, very helpful. I doubt there are many boxers who post here that still fiddle around with scripting or hardware multiplexing manually.
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