I've had somer issues with both. For one, I ended up reformatting my system drive to get my ATI series card to properly work (this was switching from nvidia, not sure if I should blame nvidia or ATI.) and for a while I had to use old ati drivers to multibox properly.
But nvidia locking out ATI users from running ati cards with a nvidia card just for physx was just stupid. And I never really jumped onto the physx bandwagon.
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