I'm using a "click castsequence" for my destruction warlock.
Click 1 = Curse of the Elements
Click 2 = Immolate
Click 3 = Conflagrate
Click 4 = Chaos Bolt
Click 5 = Incinerate
I manually remove (move) the CotE (click 1), so it is not cast on trash etc.
For bosses or tougher stuff, drag the CotE back into its position.
The click macro, also clicks trinkets when available.
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