I'm using my old 8800 GTX and my new GTX 280 in this PC right now.
With IS, I have set up a second WoW profile that homes the followers on the screen they will mostly be living and the FPS is higher than when it's just set up with a single WoW profile. However, if you use PiP and swap them off this screen and onto the main screen their FPS is lower compared to the single profile method - since now they are trying to render cross-cards to get into that spot.
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