edit: I treated the problem backwards.
For general startup/shutdown laziness, I would look at hardware installation (drivers) and software installation (the Registry)
original text:
6gb RAM / 4 clients caught my eye.
Even though the G15 isn't reporting 100% RAM utilization, I'd look for memory hard faults (a sign that Vista is using the pagefile) thus putting more stress on your HD.
Also, overclocking is your friend.
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