Originally Posted by
Noids
Focus based setup can still be leaderless and generally involve less complicated macros than FTL setups. Focus is always set to the leader or active toon and your window swap hotkey automatically switches your focus to the new active window.
The advantage to having a focusless setup is that your focus is freed up to be allocated to cc or focus dps targets.
The advantage to targetless setup is that your selected target is not kept targeted the entire time making it slighty more difficult for the enemy to anticipate target changes etc.
Both of these setups can be hard coded to a single leader or made leaderless as described above.