Here's the situation...

Previous Setup:
Window Vista 32bit
4x1024MB Crucial Balistix DDR2-800mhz (4gig total)
Asus M2N32-SLI Mobo
AMD Phenom 9600 (BE) Quad core
Nvidia 8800 GTS 640mb Video card
2x Raptor 150gb HD (1 drive OS, 1 drive for 5xWOW with only the data/interface directories shared)
1920x1200 for main on 24", 1280x1024 split 4 ways on second lcd 19" for other characters (all in windowed mode)
FPS: 25-30 on main, 20 on the 4 others.

This was "OK" but not the greatest, so I upgraded a few parts...

Current Setup:
Windows Vista x64 (Completely clean install from scratch using all 64bit drivers for all components) w/Service Pack 1
4x2048MB Corsair Dominator DDR-1066Mhz (8 gig total)
Asus M3N-HT Deluxe Mobo
AMD Phenom 9600 (BE) Quad core
Nvidia 8800 GTS 640mb Video card
2x Raptor 150gb HD (same setup, but drives are now setup as RAID 0 striped)
FPS: 16-20 on main (windowed mode)... not even running any other toons.
FPS: 30-40 in full screen mode.

Conclusion
WTF? Faster memory, faster hard drive setup, better motherboard and extremely lower FPS due to Vista x64?