in keyclone, on the maximizer layout panel, each region can specify the game resolution at the bottom under the PiP hotkey.

if you do not want your game screen to look squashed, make the region size, specified in the upper right (w,h), a multiple of the game resolution. personally, i make the game resolution the same as my biggest region... and i make my smaller regions multiples of that.

so... if my main region was 800x600 .. my smalls might be 400x300

if you need more info, please feel free to drop me a note.

Rob