Paly I use ERTFGVB for my main abilities then some shift state variations. I really like this setup because it doesn't interfere in any way with typical WASD movement or mouse look. For everything but the E key its all pointer finger around in a half moon shape. It does on the other hand require you to remap some things like reply etc but to me it's very worth it. the C key could also be added into the useable keys but for some reason I don't like the feel of it so I took it out.

Looking at it how it sits on the keyboard gives a better idea of how ergonomic this setup is. Red is the hotkeys and Green is the movement keys.
QWERT
ASDFG
ZXCVB

For the shamans I use the good ole standard 1 through = and shift states.