I currently just use party1 for all my macros (will be switching to focus with a party1 fallthrough once i get to 70) and I put similar spells on the same place on the hotbar. WIth my locks, they have a castsequence dps "i win" button that I just mash, which coincides with my paladin healer's Flash of Light (targeting the tank's target's target) so I'm always healing the one with aggro (saved my butt a few times) and I just mouse over if I Need to do anything more complex. My mixed class team I went with more of a "casting time" theme, so I have a "long cast" dps button that I use as an opener, and a "short cast" that i spam more often. I also made an "aoe" button which spams consecrate, arcane explosion, fire nova totem, and holy nova. I also just put in a castsequence for my druid to cast instant HoTs sequentally and it's tied to the aoe button, so when im just rolling places and don't want to micro, I just spam that button. I also did some round robin CC macros, which come in handy (given the limitations on certain classes CC,