Quote Originally Posted by Ughmahedhurtz
Well, with SuperMacro, you can make a TON of macros, so you could have separate macros for each. Then for your hotbars, you can select multiple hotbars (SHIFT+1/SHIFT+2/etc.) that you can set up with different buttons dropped on 'em. That should give you most of what you're after.
I'll have to check out SuperMacro, the built in account/individual macro limitation was quite frustrating. I think I can make different macros for the default 12 buttons based on solo/dual-box play, and swap the macro files depending on how I'm playing. Anyone know if you can swap the macro file and do a /console reloadui to get the new ones to load, or if you have to completely restart WoW?

As far as multiple hotbars, I already use all 120 buttons (UI Screenshot)