Ok. so I messed with it a bit, and I changed some settings and I think I know what the problem is.

Well, with 4 toons it seems to be pushing it I guess, not sure why with my rig, but it seems to be pushing it.
I lowered the Res on all 4 mons to 1280 X 1025
It helped I think, but I still get low FPS.

On the Video card sitting on the 16X slot, I get 18 FPS with 10/30 setting, but with the one on the 8X I get 9, so of course, that would be half of what the 16X gets.

But the second I drop one of the toons on the 8X card, the rest jump in frames, basically the 9 frames from that screen go to the other toons, so 18 goes to 27 and the 9 goes to 18.
Now, if I drop one of the toons on the 16X, it does nothing... lol.