macro-wise, there is another level if you are using the /assist and /follow combo.

starting out, using just 2 macros reduces the amount of things you need to figure out, leaving you to understand multiboxing at a deeper level... ingraining it, if you will... like the wax-on / wax-off of multiboxing. somewhere between levels 10 and 20, you'd be ready for more.

around then, you'll want to improve the performance/# keyhits... at that point, you get into using focus for all your powers... which means macros for all powers.. which increases the amount of work you need to do... but you would have tasted the fun and would be more willing to put a bit of time into creating the required macros... because you will understand what they are for