I'm five-man'ing with software only (beefy pc), so slightly different pains:
1) running through Ogrimar in the evenings (no trouble in instances, bgs etc, just the major towns)
2) Those pesky bad pulls when I have to work hard
Someone mentioned 'movement in instance boss fights'. This was a pain at first, as fights somtimes jump behind your four dps etc -- the key here is to just forget about follow during fights. Use your movement keys and rotate all of your five man around (back up, strafe, spin, you can do it all). Then after fight recollect in follow. If you have /assist in your /follow macro (say if you are using the no-focus strategy), seperate them into two macros on two keys. The reason is each time you /assist to change targets, /follow hits and will spin your slaves around facing you - and in wacky fights where aggro is all over, you need to target and move them independently. Anyway, works for me.
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