Boxing with KC is nearly the same as boxing with any other software/hardware. Each piece of software/hardware we use just emulates the same thing: a keyboard multiplexer.

Now, that's not to say that keyclone doesn't have some spiffy features -- I mean, I'd love to have a PiP swap for my hardware boxing setup. But as for it impacting the way the game is played? Not really going to do that.

WoW is WoW. No programs should be able to change that general experience. 2-boxing will be 2-boxing whether you play using hardware, software, or any other hybrid hardware/software set up.