Let me refraise... I use Vista x64 and have no problems running WOW or keyclone.
installing keyclone with the Vista ACL active was a problem for me, it wouldn't let me unzip the files and it wouldn't tell me why I couldn't unzip the files.
I hate Vista in general but if you disable all of the security junk they put into it it's not that bad. disable the ACL and use your own firewall.

The only reason I didn't use XP64 is that I couldn't possibly get xp64 to load on my newer machine. there were no drivers for the new chipsets while Vista just loaded and worked.