yes, you'll still have to click on all wows to loot and turn in quests.

but... using the mouse-click-passing hotkey can allow for keyclone to click the same (scaled) spots on all screens. this is meant as a toggle on... use it... toggle off type of option. anything else won't do what you'd want. the amount of normal, single screen type, clicking is pretty high... and click passing would normally be used less then 1% of the clicks.