I just installed Octopus on my wife's computer and was testing it out, etc. Got everything working fine except one thing, the extra buttons on my Logitech Revolution mouse were not being recognized. I have them mapped to numpad keys (for movement) and a few of the "F" keys. At first I thought that the mouse software was being finicky and such but on both Notepad and WoW launched without Octopus the programmed keys worked fine, with no problems.
Running Vista Home Premium 32b w/ SP1