Personally, I would move skinning to an alt character, simply because you can use a macro for skinning, Personally I added the command /cast [target=party1target, exists, dead] Skinning to the end of my main DPS macro, and if the target is skinnable, I run up with all in tow, and press it a couple of times, and it starts to skin (So long as party1 is targeting the mob) This might prove to be a downfall of mine one day when I accidentally have alt 4 cast on something while I'm trying to skin but, for now it works.

I went ahead and placed my main with professions that will benifit him the most with BoP items. I figure since I'll have ultimate control over all my toons items, I just drop everyones gathered mats in my guild bank, and can pull them as needed. My main (A shaman) is a blacksmith and a leatherworker, While enchanting would be nice to have ont he main, since he tends to get priority on gear anyway from instances, I felt the bonus of ring enchants wasn't enough to justify it. If you use an addon (Such as Enchantrix) it makes Enchanting on an alt -much- easier. I just dump all the green drops on him, and click yes about 100 times on enchantrix and all is DE'ed.

My Miner, and Herbalist flank my left and right side. I maximized their Minimaps (With an addon of course), and placed them as close to the edge of my main's monitor as possible to let my peripheral vision guide my route to lots of nodes =D

Of course, I'm also Penta-Boxing, giving me every profession (Now.. who do I drop something for inscribing ...)

GL!