You Lose a few things doing it this way. You won't have any way to spin everybody around for one. I use WASD to move my leader and if the mob moves out of line of sight, I use the arrow keys to spin my helpers to face them.

I bound my num pad keys (because they are useless) to totems and to my line set up. My 7 key moves toon 1 and 2 strafe left/right. My 9 key moves toon 3 and 4 strafe left/right. When everyone is bunched up, Hold 7 and 9 on keypad but let go of 7 a smidge earlier than 9. Bingo, nice straight line and I don't lose my arrow key functions!