Two issues with synergy in vista that i had:

It wouldn't work right unless i ran it (synergy) in administrator mode.

It wouldn't work right if it autoran (either on startup, or on login). I pretty much have to kill it, and restart it to get it to function. Well, autorun on login works in vista ususally, but ususally dies if you start opening windows. like wow. or firefox. hehe.

I've never used synergy in xp, so this might not necessarily be a vista issue, but i have to periodically kill synergy on the main comp and restart it, because it stops working, for no apparent reason.

thinking about trying some other program, but lazy.

Edit: I have 3x vista machines 3x xp machines. the XP machines ususally work fine, i never have to restart synergy on them. The vista machines ususally stop working if i start a program like WoW or EQ, but not always. Restarting synergy before i run it (as opposed to letting synergy just autorun on login) ususally fixes it. Main machine is vista, and i have to restart synergy every couple hours or so. Which isnt a huge deal, because i only use the mouse for looting, and i try to avoid looting with clones. hehe.

Ishar