Obviously I am not explaining myself correctly. Thanks for being patient. ;(

Typical Fight:

All Slaves have the "Main" targeted and are ready to go. I target a mob with my Main, press my "PEW PEW" button and everyone unleashes a barrage of nature based damage at the Main's target. Now I have a dead mob that needs to be looted, skinned, kicked or spat upon by someone. If I do any of these things on any character but the main, I have to "release" that slave's target. Its no longer on the Main, its now on the dead mob. So now I have a empty/skinless mob laying on the ground and a slave with no target.

Off I go on the main (everyone is still on follow) and target another mob to kill. The slave with no target just sits there as the others dps. I have to mash the Big Button again after every kill essentially to get everyone to target the main again. Its not a follow problem, its a target problem. So, my question was, would the use of /focus and setting the Main to be /focused by all Slaves solve the requirement to keep mashing the Big Button simply for the purpose of having everyone target the main? They would dps their focus target's target always, regardless of what their actual target is at the time.

I think that I know the answer and its that if I want to use a Target of Target style macro set, then I will indeed have to hit the Big Button macro after every fight where looting by a slave is involved.