In my honest opinion the best thing to do would be get Joana's or Kopp's guide (I have both) and use them to level a couple toons to 70. Get a feel of what quest have high drop rates and which quest have drop rates that suck and skip those.

Honestly though if you are boxing under RAF you can pretty much just get away with doing straight out kill quest with the very occasional collection quest. Collection quest are and will always be the bane of our existance. They aren't that bad if you are 2 or even 3 boxing but they are (poke your eyes out) terrible if you quad or penta box.