Here's how you could do it with HotkeyNet. There are two hotkeys here. The first one renames the WoW windows so HotkeyNet can manipulate them individually. The second resizes and positions them. HotkeyNet can also remove the window borders and lots of other things but I'm keeping the example short. If you want to know more, ask away.

Code:
<Hotkey Ctrl R>
<Rename "World of Warcraft" wow1>
<Rename "World of Warcraft" wow2>
<Rename "World of Warcraft" wow3>
<Rename "World of Warcraft" wow4>

<hotkey F1>
<TargetWindow wow1>
<SetWinPos 0 0>
<SetWinSize 512 384>

<TargetWindow wow2>
<SetWinPos 512 0>
<SetWinSize 512 384>

<TargetWindow wow3>
<SetWinPos 0 384>
<SetWinSize 512 384>

<TargetWindow wow4>
<SetWinPos 512 384>
<SetWinSize 512 384>