I have the processory affinity set up in Keyclone. I have my primary window set to CPU1, then all the other one are on CPU's 2,3. I don't have any on CPU 0. I read somewhere on here this was a good idea so you didnt have WoW competing with the OS for CPU time. I run off one one install, again I read on here that this was a more performant way to go. I also make sure to kill all of my background applications with the exception of Media Player to listen to music and books on CD.