Aye I had it happen with AHK and even when not multiboxing(got stuck on autorun somehow till I hit the direction I was running)

It can be funny sometimes though...I'm chasing down the Defias Messenger on Saturday...I see him running into the North-most mine...I target him and hit my assist hotkey and unshift from ghost wolf...run through a whole mob of normal Defias figuring "hey I'll be okay I got 5 on my side" and pull the whole lot of them on me while trying to Shock the Messenger before he gets inside the Mine...when I realize there's noone behind me. Cue "WTF" moment...I pan my camera around wondering wheretf they went...only to see them miles away, running ahead down the road, almost completely out of view range.

Launch Palm to Face missles, "GODDAMNIT YOU STUPID TARDS.", hit shift+W to stop them and start kiting the Messenger over to them, nearly dying in the process with 5 other defias on me besides him, barely get into range and drop stoneclaw totems to get 'em off, cast 5 rank 1 heals on main to get him up n running then proceed to wtfpwn them and loot my quest item. lol