I just started 2-boxing with a Nostromo N52 at my left hand, G15 center and an Ergodex DX1 at my right hand. The Ergodex controls Box2 but I have it on an Iogear USB switcher so I can use it on Box1 if desired. I use Multiplicity for switching the trackball, G15 and N52. I use Multibox for broadcasting but right now only for beginning combat and silly things like emotes and jumping.