EQ2 is much easier then EQ1 in my opinion. You can hit buttons so that a spell or skill will follow another skill which speeds up boxing. Also there is implied targeting so you can just highlight the tank and you will attack whatever he is attacking. Overall a lot easier in my opinion.
Generally most people are a bit awed when I tell them I six box. Though on occasion I run into some moron that immediately thinks I am botting. Some don't seem to know the difference.
I am running EQ2 on 6 separate computers. I am sure you could do 2 on one system. The system requirements are such I'm not sure how many more you could get to work.
I ran a berzerker, fury, and dirge for a while until I branched out and added more classes. Anything is possible really.